Search Results

Source: Archives of General Psychiatry
Resulting in 2 citations.
1. D'Onofrio, Brian M.
Rickert, Martin E.
Langström, Niklas
Donahue, Kelly L
Coyne, Claire A.
Larsson, Henrik
Ellingson, Jarrod M.
Van Hulle, Carol A.
Iliadou, Anastasia N.
Rathouz, Paul J.
Lahey, Benjamin B.
Lichtenstein, Paul
Familial Confounding of the Association Between Maternal Smoking During Pregnancy and Offspring Substance Use and Problems
Archives of General Psychiatry 69,11 (November 2012): 1140-1150.
Also: http://archpsyc.jamanetwork.com/article.aspx?articleid=1389367
Cohort(s): Children of the NLSY79, NLSY79, NLSY79 Young Adult
Publisher: American Medical Association
Keyword(s): Adolescent Behavior; Alcohol Use; Birth Order; Child Self-Administered Supplement (CSAS); Cigarette Use (see Smoking); Intergenerational Patterns/Transmission; Mothers, Behavior; Mothers, Health; Pre/post Natal Behavior; Siblings; Smoking (see Cigarette Use); Substance Use; Sweden, Swedish

Permission to reprint the abstract has not been received from the publisher.

Objective: To determine the extent to which the association between SDP and offspring substance use/problems depends on confounded familial background factors by using a quasi-experimental design.

Design: We used 2 separate samples from the United States and Sweden. The analyses prospectively predicted multiple indices of substance use and problems while controlling for statistical covariates and comparing differentially exposed siblings to minimize confounding.

Conclusions: The association between maternal SDP and offspring substance use/problems is likely due to familial background factors, not a causal influence, because siblings have similar rates of substance use and problems regardless of their specific exposure to SDP.

Bibliography Citation
D'Onofrio, Brian M., Martin E. Rickert, Niklas Langström, Kelly L Donahue, Claire A. Coyne, Henrik Larsson, Jarrod M. Ellingson, Carol A. Van Hulle, Anastasia N. Iliadou, Paul J. Rathouz, Benjamin B. Lahey and Paul Lichtenstein. "Familial Confounding of the Association Between Maternal Smoking During Pregnancy and Offspring Substance Use and Problems." Archives of General Psychiatry 69,11 (November 2012): 1140-1150.
2. D'Onofrio, Brian M.
Van Hulle, Carol A.
Waldman, Irwin D.
Rodgers, Joseph Lee
Rathouz, Paul J.
Lahey, Benjamin B.
Causal Inferences Regarding Prenatal Alcohol Exposure and Childhood Externalizing Problems
Archives of General Psychiatry 64,11 (November 2007): 1296-1304.
Also: http://archpsyc.ama-assn.org/cgi/content/abstract/64/11/1296
Cohort(s): Children of the NLSY79, NLSY79
Publisher: American Medical Association
Keyword(s): Alcohol Use; Behavior Problems Index (BPI); Behavioral Problems; Cognitive Ability; Epidemiology; Genetics; Pre/post Natal Behavior; Pregnancy and Pregnancy Outcomes; Variables, Independent - Covariate

Permission to reprint the abstract has not been received from the publisher.

CONTEXT: Existing research on the neurobehavioral consequences of prenatal alcohol exposure (PAE) has not adequately accounted for genetic and environmental confounds. OBJECTIVE: To examine the association between PAE and offspring externalizing problems in a large representative sample of families in the United States using measured covariates and a quasi-experimental design to account for unmeasured genetic and environmental confounds. DESIGN: This study combines information from the National Longitudinal Survey of Youth and the Children of the National Longitudinal Survey of Youth. The analyses statistically controlled for measured characteristics of the mothers and families and exposure to other prenatal psychoactive substances. In the primary analyses, siblings differentially exposed to prenatal alcohol were compared. SETTING AND PARTICIPANTS: Women were recruited from the community using a stratified and clustered probability sample and were followed longitudinally. The sample included 8621 offspring of 4912 mothers. MAIN OUTCOME MEASURES: Maternal report of conduct problems (CPs) and attention/impulsivity problems (AIPs) during childhood (ages 4-11 years) using standardized assessments related to psychiatric diagnoses. RESULTS: There was an association between PAE and offspring CPs that was independent of confounded genetic and fixed environmental effects and the measured covariates. The CPs in children of mothers who drank daily during pregnancy were 0.35 SD greater than those in children whose mothers never drank during pregnancy. Although AIPs were associated with PAE when comparing unrelated offspring, children whose mothers drank more frequently during pregnancy did not have more AIPs than siblings who were less exposed to alcohol in utero. Additional subsample analyses suggested that maternal polysubstance use during pregnancy may account for the associations between PAE and AIPs. CONCLUSION: These results are consistent with PAE exerting an environment ally mediated causal effect on childhood CPs, but the relation between PAE and AIPs is more likely to be caused by other factors correlated with maternal drinking during pregnancy.
Bibliography Citation
D'Onofrio, Brian M., Carol A. Van Hulle, Irwin D. Waldman, Joseph Lee Rodgers, Paul J. Rathouz and Benjamin B. Lahey. "Causal Inferences Regarding Prenatal Alcohol Exposure and Childhood Externalizing Problems." Archives of General Psychiatry 64,11 (November 2007): 1296-1304.