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Title: Smoking During Pregnancy And Offspring Externalizing Problems: An Exploration of Genetic and Environmental Confounds
Resulting in 1 citation.
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D'Onofrio, Brian M. Van Hulle, Carol A. Waldman, Irwin D. Rodgers, Joseph Lee Harden, K. Paige Rathouz, Paul J. Lahey, Benjamin B. |
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Smoking During Pregnancy And Offspring Externalizing Problems: An Exploration of Genetic and Environmental Confounds Development and Psychopathology 20,1 (Winter 2008): 139-164. Also: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1641960&fulltextType=RA&fileId=S0954579408000072 Cohort(s): Children of the NLSY79, NLSY79 Publisher: Cambridge University Press Keyword(s): Attention/Attention Deficit; Behavior Problems Index (BPI); Behavioral Problems; Cigarette Use (see Smoking); Genetics; Pregnancy and Pregnancy Outcomes; Smoking (see Cigarette Use); Variables, Independent - Covariate Permission to reprint the abstract has not been received from the publisher. Previous studies have documented that smoking during pregnancy (SDP) is associated with offspring externalizing problems, even when measured covariates were used to control for possible confounds. However, the association may be because of nonmeasured environmental and genetic factors that increase risk for offspring externalizing problems. The current project used the National Longitudinal Survey of Youth and their children, ages 4-10 years, to explore the relations between SDP and offspring conduct problems (CPs), oppositional defiant problems (ODPs), and attention-deficit/hyperactivity problems (ADHPs) using methodological and statistical controls for confounds. When offspring were compared to their own siblings who differed in their exposure to prenatal nicotine, there was no effect of SDP on offspring CP and ODP. This suggests that SDP does not have a causal effect on offspring CP and ODP. There was a small association between SDP and ADHP, consistent with a causal effect of SDP, but the magnitude of the association was greatly reduced by methodological and statistical controls. Genetically informed analyses suggest that unmeasured environmental variables influencing both SDP and offspring externalizing behaviors account for the previously observed associations. That is, the current analyses imply that important unidentified environmental factors account for the association between SDP and offspring externalizing problems, not teratogenic effects of SDP. |
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Bibliography Citation
D'Onofrio, Brian M., Carol A. Van Hulle, Irwin D. Waldman, Joseph Lee Rodgers, K. Paige Harden, Paul J. Rathouz and Benjamin B. Lahey. "Smoking During Pregnancy And Offspring Externalizing Problems: An Exploration of Genetic and Environmental Confounds." Development and Psychopathology 20,1 (Winter 2008): 139-164.
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